Peptide Secretagogue Analogs · Checked
CJC-1295 + Ipamorelin
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About CJC-1295 + Ipamorelin
CJC-1295 (No DAC) + Ipamorelin — the gold-standard GHRH + GHRP stack for natural growth-hormone release.
Research summary
CJC-1295 without DAC (Mod GRF 1-29) — clinical & mechanistic profile
Mod GRF 1-29 is a tetrasubstituted GHRH analog (Ala2, Gln8, Ala15, Leu27) with ~30-minute half-life (vs ~7 min native GHRH) due to DPP-IV resistance. Lacking DAC's albumin binding, it produces acute pulsatile GH release mimicking physiology, synergizing with GHRPs via complementary cAMP/Ca2+ pathways.
Studied applications
- Preserved pulsatility
- ~30 min half-life produces discrete GH spikes mimicking physiological patterns
- DPP-IV resistance
- Ala2 substitution blocks primary degradation enzyme, extending duration from ~7 to ~30 min
- GHRP synergy
- cAMP pathway (GHRH) + Ca2+/IP3 pathway (GHRPs) produce amplified GH pulses beyond additive effects
- Flexible protocols
- short duration allows timing with natural GH windows (sleep, exercise)
- No albumin binding
- lacks DAC moiety, enabling rapid clearance and pulsatile administration
Research constraints & safety notes
- Not approved for human therapeutic use
- Short half-life requires 2-3 daily injections for meaningful effects
- No completed human clinical trials for this specific compound
- Quality and purity of research compounds varies
- Optimal dosing and timing protocols not established
Product Description
What CJC-1295 without DAC (Mod GRF 1-29) is
CJC-1295 without DAC (Mod GRF 1-29) is a synthetic 29-amino acid GHRH analog (tetrasubstituted). Mod GRF 1-29 is a tetrasubstituted GHRH analog (Ala2, Gln8, Ala15, Leu27) with ~30-minute half-life (vs ~7 min native GHRH) due to DPP-IV resistance. Lacking DAC's albumin binding, it produces acute pulsatile GH release mimicking physiology, synergizing with GHRPs via complementary cAMP/Ca2+ pathways. It has a molecular formula C152H252N44O42, mass 3367.95 Da. Common synonyms in the literature include Mod GRF 1-29, Modified GRF, and CJC-1295 no DAC. This SKU is a co-formulated blend that also contains Ipamorelin in the same vial — for research groups that want to combine the two under a single reconstitution.
What it’s studied for
Investigation of CJC-1295 without DAC (Mod GRF 1-29) to date is primarily preclinical, with the majority of citations concentrated in animal models and in-vitro assays rather than randomized controlled human trials. Published work referencing CJC-1295 without DAC (Mod GRF 1-29) spans Structure-activity research: Studies established that Ala2 substitution prevents cleavage by dipeptidyl peptidase IV (DPP-IV), the primary GHRH-degrading enzyme. The other substitutions (Gln8, Ala15, Leu27) further enhance stability without compromising receptor binding, Combination research: Preclinical and anecdotal studies suggest GHRH + GHRP combinations produce synergistic GH release. The distinct signaling pathways (cAMP vs. calcium) converge on somatotrophs to amplify secretion beyond additive effects, and Pulsatility preservation: Unlike CJC-1295 DAC, the short half-life of Mod GRF 1-29 allows discrete GH pulses when administered 2-3 times daily. This mimics normal physiological secretion patterns more closely than sustained-release compounds. Proposed mechanisms in the literature include GHRHR full agonism: binds pituitary GHRH receptor, triggering Gs-protein coupling and adenylyl cyclase and cAMP/PKA pathway: adenylyl cyclase → cAMP → PKA activation → GH gene transcription and vesicle release. None of this material describes therapeutic outcomes in humans, and No vendor listed here provides dosing guidance for CJC-1295 without DAC (Mod GRF 1-29) outside laboratory research.
Related research
For the full mechanistic profile, published references, and constraint notes on CJC-1295 without DAC (Mod GRF 1-29), see the CJC-1295 without DAC (Mod GRF 1-29) research page. All references cited on that page are peer-reviewed primary literature.
For research use only. This summary is a research-scientific overview compiled from peer-reviewed sources. It is not medical advice and is not intended for human or veterinary consumption.
Specifications
| Attribute | Value |
|---|---|
| Molecular Formula | C152H252N44O42 + C38H49N9O5 |
| Molecular Weight | 3367.97 + 711.85 g/mol |